Top 50 Ranked Cartoon Girl Duos in Animation History

The best cartoon girl duos have captivated audiences over the years, inspiring countless young women to embrace animation as a vibrant artistic medium. These dynamic pairs have established some of the most unforgettable characters in the history of animated series and films. While male collaborations and boy-girl teams are often in the spotlight, female character pairings are surprisingly less frequent. Typically, girls in animation appear in groups or as solo entities, which makes the standout duos all the more noteworthy.

From timeless figures like those in The Flintstones and Scooby-Doo to iconic heroines from Disney and Pixar films, each remarkable cartoon girl duo presents a distinct narrative. Their relationships range from best friends and sisters to mother-daughter combos, even extending to grandmother-granddaughter pairs. Regardless of their interactions—whether comedic, heartwarming, or a blend of both—these duos leave a lasting impression on viewers.

50 Scardelita & Adelita

The Book Of Life (2014)

In *The Book Of Life*, directed by Jorge R. Gutierrez, there’s a delightful comparison to Disney’s *Coco*. Both films explore the Mexican Land of the Dead, but *The Book Of Life* boasts a unique flavor through its eccentric characters such as twins Scardelita and Adelita. These spirited cousins, who perished while defending Emiliano Zapata during the Mexican Revolution, are known for their comical bickering as they battle foes.

With their vibrant personalities, Scardelita (voiced by Sandra Equihua) and Adelita (voiced by Anjelah Johnson) are not only entertaining but also deserving of their own spinoff series, given their captivating charm.

49 The Ugly Stepsisters

Cinderella (1950)

No discussion of memorable animated female duos would be complete without addressing the Ugly Stepsisters from Disney’s classic *Cinderella*. Renowned for their comedic relief, these characters, Drizella and Anastasia, are hardly ever seen apart, and they bring a humorous mischief to Cinderella’s story.

Even as antagonists, their over-the-top antics provide some of the film’s most iconic moments, establishing them as standout figures alongside Cinderella and the Fairy Godmother.

48 Veronica & Trixie

The Fairly OddParents (2001-2016)

From Nickelodeon, *The Fairly OddParents* featured a memorable duo in high school cheerleaders Trixie and Veronica. Their dynamic is less about emotional ties and more about the comedic chaos they create. Trixie embodies the popular girl archetype, while her best friend Veronica harbors secret feelings for Timmy Turner, creating a humorous tension amidst their high school misadventures.

47 Barbara Gordon & Harleen Quinzel

DC Super Hero Girls (2019-Present)

In the animated series *DC Super Hero Girls*, Barbara Gordon (Batgirl) and Harleen Quinzel (Harley Quinn) present an intriguing friendship that flips conventional hero-villain dynamics on their head. As they navigate their contrasting moral compasses, the pair shares genuine moments of camaraderie that soften Harley’s villainy and highlight Barbara’s compassionate nature.

46 Peggy & Luanne

King Of The Hill (1997-2009)

Peggy and Luanne from *King Of The Hill* offer a rare aunt-niece duo that evolves into a mother-daughter-like relationship, despite Luanne’s childlike innocence contrasting with Peggy’s prudence. Their comedic exchanges, underlined with genuine affection, create some of the show’s most memorable moments.

45 Hayley & Francine

American Dad (2005-Present)

In *American Dad*, the mother-daughter duo of Hayley and Francine Smith delivers plenty of laugh-out-loud moments due to their peculiar and often chaotic relationship. Their interactions frequently reveal Francine’s rebellious past, with Hayley’s unyielding spirit serving as a comedic reminder of her mother’s youthful antics.

44 Laurel & Corey

Onward (2020)

Laurel and Corey from *Onward* represent a refreshing take on female friendship among adults. Laurel, voiced by Julia Louis-Dreyfus, embarks on a magical quest alongside Corey, a reformed manticore voiced by Octavia Spencer. Their evolving companionship is punctuated with moments of humor and heartfelt collaboration.

43 Ami & Yumi

HiHi Puffy AmiYumi (2004-2006)

Inspired by the real-life Japanese pop duo, *Hi Hi Puffy AmiYumi* presents an animated version of its eponymous characters, showcasing their whimsical adventures. The quirky contrast between Ami’s cheerful personality and Yumi’s more rebellious nature lends a delightful charm to their friendship, making them a unique animated pair.

42 Mei & Ming

Turning Red (2021)

In *Turning Red*, the relationship between 13-year-old Mei (Rosalie Chiang) and her mother Ming (Sandra Oh) is at the film’s heart. Their journey encapsulates the struggles of adolescence and the complexity of maternal bonds, presenting a relatable narrative enhanced by humor and warmth.

41 Sophie & The Witch Of The Wastes

Howl’s Moving Castle (2004)

In Hayao Miyazaki’s *Howl’s Moving Castle*, the evolving relationship between Sophie and the Witch of the Wastes brings depth to their characters. Initially adversaries, an unexpected bond forms when their fates intertwine, exemplifying the themes of redemption and companionship that highlight their shared journey.

40 Rogue & Shadowcat

X-Men: Evolution (2001-2003)

Within *X-Men: Evolution*, Rogue and Shadowcat forge an unexpected yet powerful friendship, creating memorable interactions that diverge from their portrayals in other adaptations. As lifelong friends in a school setting, their camaraderie serves to highlight their unique characters, showcasing the balance of personality types and how they complement one another.

39 Robyn & Mebh

Wolfwalkers (2020)

Robyn and Mebh from *Wolfwalkers* present a beautifully crafted friendship rooted in fantasy and adventure. Robyn, a human, meets Mebh, who turns into a wolf, and together they embark on a journey that reinforces themes of friendship and bravery, making them one of the standout duos in modern animation.

38 Lois & Me

Family Guy (1999-Present)

Lois and Meg in *Family Guy* provide a contrasting mother-daughter relationship that offers comedic moments tinged with harsh truths. Their dynamic often borders on the absurd, contrasting with the more nurturing interactions found in other animated shows, allowing them to solidify their place as memorable characters in contemporary comedy.

37 Cheryl & Pam

Archer (2009-2023)

In the satirical animated series *Archer*, Pam and Cheryl embody the chaos of their workplace with their unapologetically reckless antics. This unorthodox yet hilarious partnership leads them into dangerous missions, adding a unique flavor to the show’s humor and keeping audiences entertained.

36 Princess Adora & Catra

She-Ra And The Princesses Of Power (2018-2020)

Marvel at the fierce rivalry between Princess Adora and Catra in the 2018 reimagining of *She-Ra and the Princesses of Power*. Their tumultuous past, intertwined with their roles as former allies turned adversaries, encapsulates a rich narrative that explores themes of loyalty, struggle, and personal growth.

35 Shego & Kim Possible

Kim Possible (2002-2007)

In a rare twist, Kim Possible’s rivalry with her nemesis, Shego, stands out as a celebrated pairing of adversaries in animation. Their encounters mirror the dynamic of iconic duos like Batman and the Joker, producing thrilling confrontations that remain etched in pop culture history long after the series ended.

34 Katie & Linda

The Mitchells Vs. The Machines (2021)

Known for their subtle yet profound connection, the relationship between Katie and her mother Linda in *The Mitchells vs. The Machines* reveals a strong emotional bond, even amidst the chaos of family dynamics. Their interactions underscored by genuine affection, make them a noteworthy pair in contemporary animation.

33 GoGo & Honey Lemon

Big Hero 6 (2014)

In *Big Hero 6*, GoGo and Honey Lemon exemplify how contrasting personalities can forge a strong friendship, with their interactions serving as comic relief. The stylish, thrill-seeking GoGo and the enthusiastic, bubbly Honey Lemon create a dynamic that resonates with audiences throughout the film and subsequent series.

32 Susan & Mary Test

Johnny Test (2008-2014)

Mary and Susan, the twin geniuses from *Johnny Test*, showcase a unique bond as they navigate their scientific adventures. Renowned for their twin communication style and humorous schemes, they have solidified their status as memorable animated characters during the series’ run.

31 Beth & Space Beth

Rick & Morty (2013-Present)

Distinctively, Beth and Space Beth from *Rick & Morty* are a reflection of the show’s quirky narrative style. These cloned versions of Rick’s daughter engage in outlandish adventures and explore complex themes of identity and connection, rendering them a truly unique duo in animated storytelling.

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